5 Benefits of NAD+ Therapy

NAD+ therapy has been gaining attention as a potential way to support cellular health, energy production and overall wellness. In this article, we explore the benefits of NAD+ therapy and how it may contribute to longevity, weight management, and improved energy. 

The insights provided are by Vivere's Head of Nutrition, Yusra Serdaroglu Aydin, a registered dietitian with a background in nutrition, food engineering and culinary arts. Her approach is grounded in science and shaped by a strong understanding of personalised nutrition and the human microbiome.

• NAD+ is a critical coenzyme that supports energy production and helps reduce fatigue.

• NAD+ therapy may aid in DNA repair and cellular regeneration, supporting overall longevity.

• NAD+ therapy may help slow age-related decline and support healthy ageing.

• NAD+ injections provide a direct and efficient way to restore declining NAD+ levels as we age, although professional support is always recommended.

NAD+, or nicotinamide adenine dinucleotide, is a coenzyme found in every cell of the body. It plays a vital role in energy production, helping convert nutrients into energy. Beyond its energy-related functions, NAD+ is essential for DNA repair, cell signalling and maintaining the health of mitochondria, the energy-producing structures within cells [1]. 

Learn more about NAD+ on our beginner’s guide.

As we age, NAD+ levels naturally decline, which can impact energy production and overall vitality. This decline is associated with increased fatigue, reduced physical performance and difficulty managing weight [2]. Supplementing NAD+ aims to restore or boost these levels, supporting the body's natural ability to function optimally.

One of the most recognised benefits of NAD+ therapy is its ability to enhance cellular energy production. NAD+ is a key player in metabolic pathways that convert carbohydrates, fats and proteins into ATP, the energy currency of the cell. By increasing NAD+ availability, cells can produce energy more efficiently, which may reduce fatigue and improve physical performance, stamina and recovery [3].

NAD+ plays a crucial role in brain health, supporting neurotransmitter production and neuronal function. Research suggests that maintaining adequate NAD+ levels may help improve mental clarity, focus and cognitive performance [4].

For those facing age-related cognitive decline or mental fatigue, NAD+ therapy could offer a way to support brain health. Optimising NAD+ not only benefits energy, but also helps maintain the structural integrity of neurons, which is essential for memory and learning [5].

Cells are constantly exposed to damage from environmental factors and natural processes. NAD+ is a cofactor for enzymes involved in DNA repair, including sirtuins and PARPs. By supporting these repair mechanisms, NAD+ helps maintain genomic stability and promotes cellular regeneration [6].

This function is particularly important for longevity and healthy ageing. Supporting DNA repair through NAD+ therapy may help slow cellular ageing and reduce the risk of age-related diseases.

NAD+ is intimately involved in key processes, including glycolysis, the citric acid cycle and oxidative phosphorylation. By enhancing NAD+ availability, the body can process nutrients more effectively, which may lead to improved energy levels and support for weight management [7].

Individuals struggling with concerns, such as difficulty losing weight, may benefit from NAD+ therapy. Combining NAD+ supplementation with a nutrient-dense diet and regular physical activity may further optimise outcomes.

Ageing is associated with a decline in NAD+ levels and reduced mitochondrial efficiency. NAD+ therapy may help counteract these effects by supporting mitochondrial health and enhancing cellular resilience [8].

By maintaining NAD+ levels, individuals may experience benefits such as improved skin health, better energy and enhanced recovery from daily life. These effects collectively contribute to healthier ageing and improved quality of life.

NAD+ injections provide a direct and effective way to restore NAD+ levels, which decrease significantly with age. This method bypasses digestive metabolism, allowing for rapid absorption and immediate availability in the bloodstream [9]. 

NAD+ injections are increasingly popular in the UK as a method to reduce fatigue and enhance energy. Vivere provides only UK-made premium grade NAD+ (made with 99.7% pure NAD+). You can purchase a full kit to start your NAD+ therapy today, along with refill cartridges to continue experiencing the benefits of NAD+ safely and effectively.

If you’re interested in learning more about how you could benefit from them, our beginner’s guide to NAD+ injections is a great starting point.

While NAD+ therapy is available as an external support, there are additional strategies to support NAD+ naturally. These include:

• Consuming NAD+ precursors found in foods such as niacin-rich vegetables such as mushrooms, peas, avocado and potatoes, lean meats, fish peanuts and whole grains [10]

• Intermittent fasting or caloric restriction to activate sirtuins and enhance NAD+ synthesis [11]

• Engaging in regular physical activity to stimulate mitochondrial function [12]

• Prioritising quality sleep to support cellular repair [13]

• Managing stress through mindfulness practices, meditation or relaxation techniques [14]

• Minimising alcohol consumption to preserve NAD+ availability [15]

• Heat and cold exposure, including sauna sessions or cold plunges, to support mitochondrial health [16] [17] 

Combining these lifestyle strategies with NAD+ injections can help optimise NAD+ levels safely and effectively.

NAD+ therapy may be suitable for individuals experiencing fatigue, interested in supporting cognitive function and overall cellular health. Since NAD+ levels decline significantly after 30s, it is a good time to start NAD+ therapies.

NAD+ therapy is available through clinics offering NAD+ IV drips or NAD+ injections. You can also purchase your NAD+ injections online with Vivere. There are also oral NAD+ and NAD+ precursor supplements such as NMN and NR can be found in pharmacies and online stores.

IV drips require lengthy clinic visits, while oral supplements have reduced bioavailability due to digestive metabolism, which can limit their effectiveness. NAD+ injections provide a convenient at-home option, enabling rapid and efficient restoration of NAD+ levels.

NAD+ therapy offers a promising approach to support energy production, cognitive function, and healthy ageing. By maintaining optimal NAD+ levels, individuals can enhance cellular resilience and potentially slow age-related decline. NAD+ should be considered as part of a comprehensive wellness strategy that includes nutrition, exercise and personalised health support, and commencing treatment is only advised following consultation with a professional.

"NAD+ therapy is gaining attention because it targets something fundamental to how our cells produce energy, repair damage and adapt with age. While it is not a shortcut to longevity, supporting NAD+ levels may help improve energy and cellular resilience. The key is using it thoughtfully, alongside evidence-based lifestyle habits and professional guidance".

Vivere helps you take control of your health with personalised insights from state-of-the-art gut microbiome testing, nutritional guidance, science-backed supplements, NAD+ injections and expert support. Sign up today and start living better, for longer.

[1]  NAD+ and its roles in cellular processes during ageing - PMC

[2]  NAD+ as the Link - PubMed

[3]  Role of NAD+ in regulating cellular and signaling pathways - PMC

[4]  NAD+ in Brain Aging and Neurodegenerative Disorders - PMC

[5]  Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts - PMC

[6]  NAD+ and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus - ScienceDirect

[7]  NAD+ : Bioenergetics, signaling and manipulation for therapy - PMC

[8]  The role of NAD+ and its modulation of mitochondria in aging and disease - Nature

[9]  NAD Injections - Vaccine Alliance

[10]  Niacin - Fact Sheet for Health Professionals - NIH

[11]  Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds - PMC

[12]  Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis - PMC

[13]  Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity - Frontiers

[14]  Relaxation Techniques - NCBI

[15]  Restoring energy by NAD + supplement prevents alcohol‐induced liver injury and boosts liver regeneration - PMC

[16]  Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ in humans - Cell

[17]  Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level? - PMC